Ultrafiltration Equipment For Hospitals

The core of Jingbo's Ultrafiltration Equipment for Hospitals is "molecule sieving." The ultrafiltration membrane is covered with pores ranging from 1 to 20 nanometers in size, uniformly sized and controllable. Molecules larger than the pores, such as proteins and viruses, are blocked by the membrane, forming a concentrate; smaller molecules like water and salt can pass through directly, becoming the permeate. The key is the "molecular weight cutoff," which is the smallest molecule the membrane can block at least 90%, expressed in Daltons. For example, a 10kD membrane will retain antibodies larger than 10,000 Daltons, while smaller impurities will be filtered out.

The entire process takes place at room temperature, driven by pressure, and does not alter the form of substances, thus protecting the activity of biological macromolecules. There are two main operation methods: tangential flow filtration is used most of the time, where the liquid flows at high speed along the membrane surface, flushing away trapped substances and preventing membrane clogging; for small batches of samples with few impurities, dead-end filtration is used, where the liquid flows directly onto the membrane surface.

Product Parameters

Ultrafiltration equipment for hospitals has three main applications, precisely addressing the core needs of pharmaceutical production. Concentration removes water to increase the concentration of target substances such as antibodies and vaccines; percolation changes the buffer solution or removes small molecule impurities, such as continuously adding new buffer solution during production to "wash away" impurities like salts and preservatives; fractionation separates different substances according to molecular size, such as separating antibodies from unbound small molecule drugs. If used for vaccine production, the equipment parameters are clearly defined: molecular weight cutoff 100-300 kDa, transmembrane pressure 0.5-1.5 bar, tangential flow rate 1-2 m/s, and operating temperature controlled at 2-8°C.

This Ultrafiltration Equipment for Hospitals is manufactured according to GMP standards for pharmaceutical production. All parts in contact with materials are made of safe materials, such as 316L stainless steel and USP Class VI compliant plastics. The connections are clean, eliminating blind spots and minimizing residue buildup. It also supports online sterilization, using pure steam at 121°C for 30 minutes to ensure aseptic production. Online cleaning is also supported; acid and alkaline cleaners can remove contaminants, preventing cross-contamination between different batches. The equipment's compact piping design minimizes dead volume, reducing product waste and achieving a yield of over 98%, making it particularly cost-effective for pharmaceutical companies.